San Antonio Missions National Historical Park

Mission San José y San Miguel de Aguayo is an historic Catholic mission in San Antonio, Texas, United States. The mission was named in part for the Marquis de San Miguel de Aguayo, José de Azlor y Virto de Vera. Many buildings on the campus of Texas Tech University in Lubbock, Texas, borrow architectural elements from those found at Mission San José.

The mission was founded on February 23, 1720, because Mission San Antonio de Valero had become overcrowded shortly after its founding with refugees from the closed East Texas missions. Father Antonio Margil received permission from the governor of Coahuila and Texas, the Marquis de San Miguel de Aguayo, to build a new mission 5 miles south of San Antonio de Valero. Like San Antonio de Valero, Mission San José served the Coahuiltecan Natives.