The Blue Brain Project is a Swiss brain research initiative that aims to create a digital reconstruction of rodent and eventually human brains by reverse-engineering mammalian brain circuitry. The project was founded in May 2005 by the Brain and Mind Institute of École Polytechnique Fédérale de Lausanne in Switzerland. Its mission is to use biologically-detailed digital reconstructions and simulations of the mammalian brain to identify the fundamental principles of brain structure and function.
The project is headed by the founding director Henry Markram—who also launched the European Human Brain Project—and is co-directed by Felix Schürmann and Sean Hill. Using a Blue Gene supercomputer running Michael Hines's NEURON software, the simulation involves a biologically realistic model of neurons and an empirically reconstructed model connectome.