Holliston is a New England town in Middlesex County, Massachusetts, United States in the Greater Boston area. The population was 14,996 at the 2020 census. It is located in MetroWest, a Massachusetts region that is west of Boston. Holliston is the only town in Middlesex County that borders both Norfolk and Worcester counties.
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Coordinates 42°12'0.347" N -71°25'28.218" E