Hôpital Saint-Louis is a hospital in Paris, France. It was built in 1611 by architect Claude Vellefaux at the request of Henry IV of France. It is part of the Assistance publique - Hôpitaux de Paris hospital system, and it is located at 1 avenue Claude-Vellefaux, in the 10th arrondissement near the metro station: Goncourt. Its address is 1 avenue Claude-Vellefaux, just north of rue Bichat.
It was founded by King Henry IV on May 17, 1607 to decongest the Hôtel-Dieu de Paris during the plague. He named it St. Louis in memory of Louis IX, who died of the dysentery that devastated Tunis in 1270.