La Crosse County is a county located in the U.S. state of Wisconsin. At the 2020 census, the population was 120,784. Its county seat is La Crosse. La Crosse County is included in the La Crosse-Onalaska, WI-MN Metropolitan Statistical Area with a population of 139,627 and is the most populous county on Wisconsin's western border.
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Coordinates 43°48'44.221" N -91°15'5.168" E