The Lauffen bus crash of 20 June 1959 resulted in the deaths of 45 people. At the time it was the worst accident involving a bus since the end of the Second World War.
A bus chartered by German Railways on a regular service collided with an express train on the Tübingen to Würzburg route at level crossing number 47 at Lauffen am Neckar. In all, 45 persons were killed and 27 others were seriously injured.
The bus was operating a rail replacement service for the Zabergäu Railway along the stretch from Leonbronn to Lauffen. A timetable reduction had been introduced along this narrow gauge line in 1954.
Wikipedia https://en.wikipedia.org/wiki/Lauffen_bus_crash
Address 4 Heimstraße, Lauffen am Neckar 74348, Germany
Coordinates 49°4'10.866" N 9°8'1.261" E