This part of New York got its name from its immigrant population, mainly consisting of Italian Americans. Today, however, the number of inhabitants of Italian descent is not significantly higher than in the rest of New York. The place is still worth visiting though because the Italian atmosphere is still very present and alive.
During your visit, you can taste the Italian cuisine in one of the ever present Italian restaurants or cafés. There are also many wine-related events (e.g. wine tasting) organised. If you would like to learn more about the history of the Italian community in the USA, you should visit the Italian American Museum which provides interesting information on this topic.
If you visit the place in the second half of September, you might get to see the Feast of San Gennaro which takes place in Little Italy and celebrates the Italian community and its culture.
Official website http://www.littleitalynyc.com/
Coordinates 40°43'9.796" N -73°59'53.592" E