Opheylissem Castle is a large stately home in Opheylissem in the municipality of Hélécine, Walloon Brabant, Belgium.
The present building represents the remains of the former Premonstratensian Opheylissem Abbey, which was dissolved in 1796. Most of the buildings were destroyed, but the abbot's house remained, and in 1870 was restructured by the architect Alphonse Balat in its present form. Balat laid out the surrounding park at the same time.
The house and park were acquired by the Province of Brabant, and after 1995 became that of the Province of Walloon Brabant.
Coordinates 50°44'47.206" N 4°58'45.174" E