When you arrive in Venice by car, this is usually the first square that you can see. It also serves as the main bus station and generally an important transport hub. It might get hectic during the rush hours when there are lots of commuters walking to and from.
Wikipedia https://en.wikipedia.org/wiki/Piazzale_Roma
Address 456D Piazzale Roma, Venezia 30135, Italy
Coordinates 45°26'16.548" N 12°19'7.977" E